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January 2012 Briefing - Internal Medicine
Here are what the editors at HealthDay consider to be the most important developments in Internal Medicine for January 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Diabetes Drugs Affect Pancreatic Cancer Risk
TUESDAY, Jan. 31 (HealthDay News) -- Long-term use of the diabetes drug metformin is associated with a lower risk of pancreatic cancer only in women, while long-term use of sulfonylureas and insulin are associated with a significantly higher risk of pancreatic cancer, according to a study published online Jan. 31 in the American Journal of Gastroenterology.
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Fenofibrate Found Safe in Diabetes With Renal Impairment
TUESDAY, Jan. 31 (HealthDay News) -- Long-term daily use of fenofibrate is beneficial for patients with type 2 diabetes and moderate renal impairment and is not associated with an increase in drug-related safety concerns compared with those with mild renal impairment, according to research published in the February issue of Diabetes Care.
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Safety-Net Status Not Linked to ER Length of Stay
TUESDAY, Jan. 31 (HealthDay News) -- There is no significant difference in compliance with emergency department length-of-stay measures for admissions, discharges, observations, and transfers between safety-net and non-safety-net hospitals, according to a study published in the Feb. 1 issue of the Journal of the American Medical Association.
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Breast Reexcision Rates Vary With Surgeon, Institution
TUESDAY, Jan. 31 (HealthDay News) -- For women with invasive breast cancer who undergo partial mastectomy and have negative margins, reexcision rates vary substantially depending on the surgeon and institution, according to a retrospective chart review published in the Feb. 1 issue of the Journal of the American Medical Association.
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Physician Overweight/Obesity Impacts Obesity Care
TUESDAY, Jan. 31 (HealthDay News) -- Being overweight/obese has a significant impact on a physician's provision of obesity care, according to a study published online Jan. 19 in Obesity.
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Laparoscopy Acceptable for Staging Uterine Cancer
TUESDAY, Jan. 31 (HealthDay News) -- Comprehensive surgical staging of endometrial cancer can be performed laparoscopically with relatively small differences in recurrence rates compared to laparotomy, according to a study published online Jan. 30 in the Journal of Clinical Oncology.
Site of Fatty Acid Storage in the Body Varies With Activity
TUESDAY, Jan. 31 (HealthDay News) -- During eating, free fatty acids are preferentially stored in upper-body fat in both men and women, but during walking they are preferentially stored in lower-body fat in women, according to a study published in the February issue of Diabetes.
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Cyberknife Effective in Treating Trigeminal Neuralgia
TUESDAY, Jan. 31 (HealthDay News) -- Cyberknife stereotactic radiosurgery is effective in the treatment of trigeminal neuralgia (TN), according to a small study published online Jan. 25 in the Journal of NeuroInterventional Surgery.
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High-Fiber Diet May Not Lower Risk of Diverticulosis
TUESDAY, Jan. 31 (HealthDay News) -- High dietary fiber intake was not associated with a lower prevalence of diverticulosis. In fact, people who ate a high-fiber diet and those having 15 or more bowel movements per week had a higher, not lower, prevalence of diverticulosis, according to research published in the February issue of Gastroenterology.
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Meta-Analysis: Statin Therapy Equally Effective in Women, Men
MONDAY, Jan. 30 (HealthDay News) -- Statin therapy is equally effective for decreasing cardiovascular events in women and men, according to a meta-analysis published in the Feb. 7 issue of the Journal of the American College of Cardiology.
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Antiretroviral Medications Linked to Cleft Deformities
MONDAY, Jan. 30 (HealthDay News) --Antiretroviral drugs prescribed for HIV-infected pregnant women to reduce risk of mother-to-child disease transmission may be linked to cleft lip and palate disorders in newborns, according to a study published in the January issue of Cleft Palate-Craniofacial Journal.
Disc Degeneration More Likely in Overweight, Obese Adults
MONDAY, Jan. 30 (HealthDay News) -- Overweight and obese adults are significantly more likely to have lumbar disc degeneration compared with those who have a normal body mass index (BMI), according to a study published online Jan. 27 in Arthritis & Rheumatism.
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Education Reduces Distress During Breast Cancer Treatment
MONDAY, Jan. 30 (HealthDay News) -- Interventions such as telephone counseling can help women with early-stage breast cancer adjust to emotional distress stemming from the side effects of treatment, according to a study published in the February issue of Applied Nursing Research.
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Preventive Health Services Missed in Half of Patients
MONDAY, Jan. 30 (HealthDay News) -- During periodic health examinations (PHEs), a variety of patient, physician, and visit factors together affect the recommendation and delivery of evidence-based preventive health services, with patients receiving only about half of those services for which they are due, according to research published in the February issue of the American Journal of Preventive Medicine.
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Family Teamwork Gives Valued Boost to Senior Care
MONDAY, Jan. 30 (HealthDay News) -- Family companions involved in physician visits with older adults usually offer task assistance in activities of daily living (ADLs) and can help build patient-provider partnerships to efficiently manage senior health, according to a study published in the January issue of the Journal of the American Geriatrics Society.
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Bydureon Approved for Type 2 Diabetes
FRIDAY, Jan. 27 (HealthDay News) -- Bydureon (exenatide extended release), Amylin Pharmaceuticals' long-acting version of the diabetes drug Byetta, has been approved by the U.S. Food and Drug Administration.
Self-Rated Health Status Predicts Mortality Among CVD Patients
FRIDAY, Jan. 27 (HealthDay News) -- Self-rated health status is a risk factor for future vascular events and mortality in patients with cardiovascular diseases, particularly in those with asymptomatic atherosclerotic disease, according to a study published online Jan. 18 in the Journal of Internal Medicine.
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Isoflurane Harmful to Mitochondrial Function in Mice
FRIDAY, Jan. 27 (HealthDay News) -- Anesthetics isoflurane and desflurane have distinct effects on mitochondrial function and learning and memory, according to an experimental study published online Jan. 19 in the Annals of Neurology.
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COPD Assessment Test Predicts Exacerbation Severity
FRIDAY, Jan. 27 (HealthDay News) -- The COPD Assessment Test (CAT) provides a reliable score of exacerbation severity in patients with chronic obstructive pulmonary disease (COPD), according to a study published online Jan. 26 in the American Journal of Respiratory and Critical Care Medicine.
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Steroid-Sparing Renal Transplant Yields Successful Outcomes
FRIDAY, Jan. 27 (HealthDay News) -- Rapid discontinuation of prednisone (RDP) five days after renal transplantation from a living (LD) or deceased donor (DD) yields acceptable 10-year patient and graft outcomes, according to research published online Jan. 26 in the Clinical Journal of the American Society of Nephrology.
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No Complications From Using Stored Red Blood Cells
FRIDAY, Jan. 27 (HealthDay News) -- There is no significant difference in early complications, including measures of pulmonary function, immunologic status, or coagulation status, after using fresh versus standard issue red blood cell (RBC) transfusions, according to a study published online Jan. 26 in the American Journal of Respiratory and Critical Care Medicine.
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Polypectomy Outcomes Similar to Surgical Resection
FRIDAY, Jan. 27 (HealthDay News) -- For patients with malignant colonic polyps who have similar clinical characteristics, management with either polypectomy or surgical resection results in comparable outcomes, according to a study published in the Feb. 1 issue of Cancer.
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Comparable Clinical Activity for Low-, High-Dose Clofarabine
FRIDAY, Jan. 27 (HealthDay News) -- Low and high doses of clofarabine have comparable clinical activity for the treatment of patients with higher-risk myelodysplastic syndrome (MDS), according to a study published in the Feb. 1 issue of Cancer.
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New PCR-Based Assay Better Predicts Lung Cancer Survival
FRIDAY, Jan. 27 (HealthDay News) -- A new quantitative polymerase chain reaction (PCR)-based assay can better identify which patients with early-stage non-small-cell lung cancer (NSCLC) are at higher risk of mortality after surgical resection, according to a study published online Jan. 27 in The Lancet.
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Warfarin Use Lowers Mortality in Septuagenarians With A-Fib
FRIDAY, Jan. 27 (HealthDay News) -- In a group of septuagenarian patients with atrial fibrillation, followed for up to six years, warfarin use is associated with a significant reduction in all-cause mortality, according to a study published in the Feb. 1 issue of The American Journal of Cardiology.
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More Than 40 Percent of Adults With RA Are Inactive
THURSDAY, Jan. 26 (HealthDay News) -- More than 40 percent of adults with rheumatoid arthritis (RA) are inactive, with lack of both strong motivation and belief in physical activity accounting for most of the excess inactivity, according to a study published online Jan. 25 in Arthritis Care & Research.
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Decline in Rate of Diabetic Lower-Extremity Amputation
THURSDAY, Jan. 26 (HealthDay News) -- From 1996 to 2008 there was a decline in the rates of hospitalization for nontraumatic lower-extremity amputation (NLEA) in the U.S. population with diabetes, according to a study published in the February issue of Diabetes Care.
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ACE Inhibitors Not Linked to Improved Outcomes After ACS
THURSDAY, Jan. 26 (HealthDay News) -- For patients with acute coronary syndrome (ACS), prior chronic use of an angiotensin-converting enzyme (ACE) inhibitor is not independently associated with improved in-hospital outcomes, according to a study published in the Feb. 1 issue of The American Journal of Cardiology.
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Oral HPV Infection Prevalence in U.S. Close to 7 Percent
THURSDAY, Jan. 26 (HealthDay News) -- In the United States, the prevalence of oral human papillomavirus (HPV) infection is 6.9 percent, with higher prevalence in men than women, according to a study published online Jan. 26 in the Journal of the American Medical Association.
Survival Reduced for Patients With Cancer Who Have Diabetes
THURSDAY, Jan. 26 (HealthDay News) -- Patients with cancer generally have reduced survival if they also have type 2 diabetes, although this depends on the type of cancer and diabetes treatment, according to a study published online Jan. 20 in Diabetes Care.
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Long Working Hours Linked to Increased Risk of Depression
THURSDAY, Jan. 26 (HealthDay News) -- Working 11 or more hours a day is associated with a significant increase in the likelihood of a major depressive episode (MDE) among British civil servants, compared with working a seven to eight hour day, according to a study published online Jan. 25 in PLoS One.
Deaths From Myocardial Infarction Halved in England
THURSDAY, Jan. 26 (HealthDay News) -- From 2002 to 2010 in England, there was a decrease of about half in the total mortality rate for acute myocardial infarction, according to a study published online Jan. 25 in BMJ.
Mutations in IDH1/2 Seen in Intrahepatic Bile Duct Cancers
THURSDAY, Jan. 26 (HealthDay News) -- Mutations in genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are present in about a quarter of biliary tract carcinomas arising within the liver, according to a study published online Dec. 16 in The Oncologist.
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Exposure to Iodinated Contrast Media Affects Thyroid Function
THURSDAY, Jan. 26 (HealthDay News) -- Exposure to iodinated contrast media (ICM), which are frequently used during imaging procedures, is associated with changes in thyroid function, specifically an increased risk of developing incident hyperthyroidism and incident overt hypothyroidism, according to a study published in the Jan. 23 issue of the Archives of Internal Medicine.
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Positive Affirmation Improves Medication Adherence
THURSDAY, Jan. 26 (HealthDay News) -- Patient education (PE) enhanced with positive affirmation (PA) improves medication adherence over education alone in African-Americans with hypertension, but it does not lead to significant improvements in blood pressure (BP) reduction, according to a study published online Jan. 23 in the Archives of Internal Medicine.
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Risk-Factor Burden Impacts Lifetime Risk of Cardio Disease
WEDNESDAY, Jan. 25 (HealthDay News) -- Variation in risk-factor burden results in considerable differences in the lifetime risk of cardiovascular disease, and these differences are consistent across race and birth cohorts, according to a meta-analysis published in the Jan. 26 issue of the New England Journal of Medicine.
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Bevacizumab Efficacious for HER2-Negative Breast Cancer
WEDNESDAY, Jan. 25 (HealthDay News) -- For patients with human epidermal growth factor receptor 2 (HER2)-negative breast cancer, the addition of bevacizumab to neoadjuvant chemotherapy improves the pathological complete response (pCR), according to two studies published in the Jan. 26 issue of the New England Journal of Medicine.
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Men at Higher Risk for Mild Cognitive Impairment
WEDNESDAY, Jan. 25 (HealthDay News) -- The incidence of both amnestic and nonamnestic mild cognitive impairment (aMCI and naMCI) is higher in men than women, according to a study published online Jan. 25 in Neurology.
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Neurologists Should Routinely Assess Patients for Abuse
WEDNESDAY, Jan. 25 (HealthDay News) -- Neurologists should evaluate patients for abuse and neglect, according to a position statement issued by the American Academy of Neurology published online Jan. 25 in Neurology.
Overuse of Health Care Services Understudied
WEDNESDAY, Jan. 25 (HealthDay News) -- Overuse of health care services in the United States is an understudied problem, with the majority of research limited to a few interventions, according to a review published in the Jan. 23 issue of the Archives of Internal Medicine.
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Sex Differences Exist in Disease-Linked Pain Intensity
WEDNESDAY, Jan. 25 (HealthDay News) -- Sex differences exist in specific disease-associated pain intensity, with women suffering a higher prevalence of pain for musculoskeletal, neuropathic, abdominal, and migraine-related conditions, according to a study published online Jan. 16 in The Journal of Pain.
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Oxaliplatin Improves Survival for Colorectal Cancer Patients
WEDNESDAY, Jan. 25 (HealthDay News) -- The addition of oxaliplatin to 5-fluorouracil (5-FU) improves survival for stage III colon cancer patients in diverse practice settings, including among older and minority patients, according to a study published online Jan. 20 in the Journal of the National Cancer Institute.
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Foods Fried in Olive Oil Not Linked to Heart Disease
WEDNESDAY, Jan. 25 (HealthDay News) -- Eating foods fried in olive or sunflower oil is not linked to heart disease or all-cause mortality, according to a Spanish study published online Jan. 24 in BMJ.
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BRCA Carriers Have Improved Survival in Ovarian Cancer
TUESDAY, Jan. 24 (HealthDay News) -- For patients with invasive epithelial ovarian cancer (EOC), BRCA1 and BRCA2 mutations are associated with improved five-year survival, according to a study published in the Jan. 25 issue of the Journal of the American Medical Association.
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Unemployed Have Poorer Mental and Physical Health
TUESDAY, Jan. 24 (HealthDay News) -- Unemployed adults are about half as likely to have health insurance as employed individuals; have poorer mental and physical health, regardless of their insurance status; and are less likely to receive needed medical care and prescriptions, according to a January data brief issued by the National Center for Health Statistics.
Reduced [11C]PiB Uptake in Cognitively Active Elderly
TUESDAY, Jan. 24 (HealthDay News) -- Elderly individuals who keep their brains active through activities such as reading, writing, and playing games have reduced uptake of carbon 11-labeled Pittsburg Compound B ([11C]PiB), according to a study published online Jan. 23 in the Archives of Neurology.
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Dutasteride Delays Low-Risk Prostate Cancer Progression
TUESDAY, Jan. 24 (HealthDay News) -- For men with low-risk prostate cancer who undergo active surveillance, treatment with dutasteride delays the time to cancer progression, according to a study published online Jan. 24 in The Lancet.
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HealthGrades IDs Notable Hospitals for Clinical Excellence
TUESDAY, Jan. 24 (HealthDay News) -- The top 5 percent of U.S. hospitals has more than a 30 percent lower risk-adjusted mortality across 17 procedures and diagnoses, compared with other hospitals, according to the 10th annual HealthGrades Hospital Quality and Clinical Excellence study published online Jan. 24.
Unhealthy Narcissism Linked to Elevated Cortisol in Men
TUESDAY, Jan. 24 (HealthDay News) -- Narcissism is associated with elevated levels of cortisol in men, according to a study published online Jan. 23 in PLoS One.
Negative Social Interactions Linked to Inflammation
TUESDAY, Jan. 24 (HealthDay News) -- Everyday social interactions that are negative or competitive are associated with elevated levels of inflammatory cytokines, according to a study published online Jan. 23 in the Proceedings of the National Academy of Sciences.
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Statins May Reduce Risk for HCC in Hep B-Infected Patients
MONDAY, Jan. 23 (HealthDay News) -- For hepatitis B virus (HBV)-infected patients, statin use is associated with a reduction in the risk for hepatocellular carcinoma (HCC), in a dose-dependent manner, according to a study published online Jan. 23 in the Journal of Clinical Oncology.
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Sleep Disturbance Linked to Cardiometabolic Disease Risk
MONDAY, Jan. 23 (HealthDay News) -- Sleep duration and sleep disturbance are associated with cardiometabolic disease, according to a study published online Dec. 12 in the Journal of Sleep Research.
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Mild Traumatic Brain Injury in ~4 Percent of U.K. Troops
MONDAY, Jan. 23 (HealthDay News) -- Mild traumatic brain injury (mTBI) has a prevalence of 4.4 percent in U.K. troops returning from Iraq or Afghanistan, and 9.5 percent in those with a combat role, according to a study published in the January/February issue of the Journal of Head Trauma Rehabilitation.
Substantial Minority Continue Smoking After Cancer Diagnosis
MONDAY, Jan. 23 (HealthDay News) -- A considerable minority of patients with lung and colorectal cancer continue smoking after being diagnosed, according to study published online Jan. 23 in Cancer.
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Mild-to-Moderate Asthma Frequently Non-Eosinophilic
MONDAY, Jan. 23 (HealthDay News) -- Approximately half of all patients with mild-to-moderate asthma are persistently non-eosinophilic, according to a study published online Jan. 20 in the American Journal of Respiratory and Critical Care Medicine.
Gender, Family, Ambivalence Impact Live Liver Donation
MONDAY, Jan. 23 (HealthDay News) -- Gender, relationship to the recipient, and ambivalence toward donation all impact living liver donor's decisions, motives, and post-donation outcomes, according to a study published in the January issue of the American Journal of Transplantation.
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Inadequate Hep B Vaccinations for High-Risk Adults
MONDAY, Jan. 23 (HealthDay News) -- Approximately half of all adults at high risk of hepatitis B infection are vaccinated against hepatitis B, and more than half miss opportunities to be vaccinated, according to a study published online Jan. 12 in Infection.
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Dosing Errors Occur With IV Acetaminophen in Children
MONDAY, Jan. 23 (HealthDay News) -- Use of a new intravenous formulation of acetaminophen is associated with dosing errors in neonates, infants, and small children, and evaluation and management of these dosing errors are similar to oral overdose, according to a report published online Jan. 23 in Pediatrics.
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First Test Approved to Help Detect Risk of PML
FRIDAY, Jan. 20 (HealthDay News) -- The first test to help determine the risk of a rare brain infection among users of the drug Tysabri has been approved by the U.S. Food and Drug Administration.
SSRIs Increase Fall Risk in Elderly Dementia Patients
FRIDAY, Jan. 20 (HealthDay News) -- Even at low doses, selective serotonin reuptake inhibitors (SSRIs) increase the risk of injuries due to falls in elderly dementia patients, and the risk increases further at higher doses and when hypnotics and sedatives are added, according to a study published online Jan. 18 in the British Journal of Clinical Pharmacology.
Neuromodulators Reduce Pain in Rheumatoid Arthritis
FRIDAY, Jan. 20 (HealthDay News) -- Neuromodulators are superior to placebo for reducing pain in patients with rheumatoid arthritis (RA), but treatment is associated with adverse events; whereas muscle relaxants show no benefit for improving pain in RA, according to two reviews published online Jan. 18 in the Cochrane Database of Systematic Reviews.
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Matted Lymph Nodes ID Poor Oropharyngeal SCC Prognosis
FRIDAY, Jan. 20 (HealthDay News) -- Patients with oropharyngeal squamous cell carcinoma (SCC) who present with matted nodes have a worse prognosis than those without matted nodes, according to a study published online Jan. 13 in Head & Neck.
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Warfarin Patients With Head Trauma Need Second CT Scan
FRIDAY, Jan. 20 (HealthDay News) -- For patients on warfarin with minor head trauma who have an initial negative computed tomography (CT) scan, 24-hour observation followed by an additional CT scan identifies the majority of cases of delayed bleeding, according to a study published online Jan. 16 in the Annals of Emergency Medicine.
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HIV Risk-Related Behaviors Down in the United States
FRIDAY, Jan. 20 (HealthDay News) -- The number of men and women who reported engaging in HIV risk-related behaviors was lower in 2006 to 2010 compared with 2002, with the decline likely resulting from a decrease in sexual risk behaviors, according to a research published in the Jan. 19 issue of the U.S. Centers for Disease Control and Prevention's National Health Statistics Reports.
No Autoimmune Safety Signal for Quadrivalent HPV Vaccine
FRIDAY, Jan. 20 (HealthDay News) -- For women vaccinated with the quadrivalent human papillomavirus vaccine (HPV4), there is no evidence of an autoimmune safety signal, according to a study published in the February issue of the Journal of Internal Medicine.
Sleep Tied to Maintenance of Emotional Reactivity
FRIDAY, Jan. 20 (HealthDay News) -- Sleep is associated with enhanced emotional memory and maintenance of emotional reactivity compared with wake, according to a study published in the Jan. 18 issue of The Journal of Neuroscience.
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Taking Two or More Medications Increases Fall Rate
FRIDAY, Jan. 20 (HealthDay News) -- The use of two or more prescription medications is associated with an increased risk of falls and fall-related injuries at home among young and middle-aged adults, according to a study published online Jan. 16 in Injury Prevention.
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Sexual Activity Safe for Most Cardiovascular Disease Patients
THURSDAY, Jan. 19 (HealthDay News) -- For most individuals with stable cardiovascular disease (CVD), sexual activity is safe, according to a scientific statement from the American Heart Association published online Jan. 19 in Circulation.
Worse Outcomes for Stroke Patients With Delirium
THURSDAY, Jan. 19 (HealthDay News) -- Stroke patients who develop delirium have worse outcomes, including higher mortality and longer hospitalizations, and are more likely to be discharged to a care facility, according to a review published online Jan. 19 in Stroke.
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Calcium Associated With Lower Risk of Prostate Cancer
THURSDAY, Jan. 19 (HealthDay News) -- Dietary calcium intake is inversely associated with prostate cancer risk, according to a study published online Jan. 12 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.
Cancer Prevention Guidelines Updated
THURSDAY, Jan. 19 (HealthDay News) -- The American Cancer Society (ACS) Nutrition and Physical Activity Guidelines were recently updated and published in the January/February issue of CA: A Cancer Journal for Clinicians.
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Cognitive Impairment Seen in Overweight Retired NFL Players
THURSDAY, Jan. 19 (HealthDay News) -- Overweight retired National Football League (NFL) players have decreased blood flow in certain areas of the brain as well as significant decreases in attention, cognitive proficiency, and memory, according to a study published online Jan. 17 in Translational Psychiatry.
Osteoporotic Fracture Risk High in Systemic Mastocytosis
THURSDAY, Jan. 19 (HealthDay News) -- There is a high risk of osteoporotic fractures and osteoporosis in patients with indolent systemic mastocytosis (ISM), according to a study published online Jan. 9 in Allergy.
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SAMHSA: One in Five U.S. Adults Has Mental Illness
THURSDAY, Jan. 19 (HealthDay News) -- In the United States in 2010, the prevalence of any mental illness (AMI) in the past year was 20 percent, and that of serious mental illness (SMI) was 5 percent, for individuals aged 18 years or older, according to a report published online Jan. 19 by the Substance Abuse and Mental Health Services Administration (SAMHSA).
Upper Normal BP Increases Risk for A-Fib in Men
THURSDAY, Jan. 19 (HealthDay News) -- Having blood pressure (BP) within the upper limits of normal can predict future atrial fibrillation (AF) in otherwise healthy, middle-aged men, according to a study published online Jan. 17 in Hypertension.
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Chronic Hepatitis C May Benefit From New Antivirals
THURSDAY, Jan. 19 (HealthDay News) -- Direct-acting antiviral agents may be effective for treating patients with chronic hepatitis C virus (HCV) genotype 1 who don't respond to peginterferon and ribavirin therapies, according to a study published in the Jan. 19 issue of the New England Journal of Medicine.
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Age-Related Intelligence Changes Linked to Genetics
WEDNESDAY, Jan. 18 (HealthDay News) -- Genetic factors account for some of the changes in intelligence that occur between childhood and old age, according to a letter published online Jan. 18 in Nature.
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Study IDs Optimal Interval Between Bone Density Tests
WEDNESDAY, Jan. 18 (HealthDay News) -- The recommended bone mineral density (BMD) screening interval is approximately 16 years for postmenopausal women with normal BMD, 4.5 years for women with moderate osteopenia, and one year for women with advanced osteopenia, according to a study published in the Jan. 19 issue of the New England Journal of Medicine.
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BRAF + MEK Inhibitor May Help Avoid Cutaneous Carcinomas
WEDNESDAY, Jan. 18 (HealthDay News) -- Combining the BRAF inhibitor vemurafenib with an MEK inhibitor may help prevent squamous-cell carcinomas in melanoma treatment, according to a study published in the Jan. 19 issue of the New England Journal of Medicine.
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Liver Transplant Stabilizes Lung Function in Cystic Fibrosis
WEDNESDAY, Jan. 18 (HealthDay News) -- For a select group of patients with cirrhosis due to cystic fibrosis liver disease (CFLD), liver transplantation can stabilize long-term lung function and nutritional status and reduce the need for intravenous antibiotics, according to a study published online Jan. 6 in the American Journal of Transplantation.
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Psychosocial Interventions Reduce Cancer Pain in Adults
WEDNESDAY, Jan. 18 (HealthDay News) -- For adults with cancer, psychosocial interventions have a positive effect on pain severity and pain interference, according to a meta-analysis published online Jan. 17 in the Journal of Clinical Oncology.
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Rates of Post-Arthroplasty Symptomatic VTE Identified
WEDNESDAY, Jan. 18 (HealthDay News) -- The rates of postoperative symptomatic venous thromboembolism (VTE) are 1.09 percent after total or partial knee arthroplasty (TPKA) and 0.53 percent after total or partial hip arthroplasty (TPHA), according to a review published in the Jan. 18 issue of the Journal of the American Medical Association.
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Cybercycling Improves Cognitive Function in Elderly
WEDNESDAY, Jan. 18 (HealthDay News) -- Virtual reality-enhanced exercise, or "exergames," such as cybercycling, is associated with a greater cognitive benefit for older adults than traditional exercise, according to a study published online Jan. 17 in the American Journal of Preventive Medicine.
Platelet Inhibition Maintained With Pre-CABG Cangrelor
TUESDAY, Jan. 17 (HealthDay News) -- For patients who discontinue thienopyridine treatment before coronary artery bypass graft (CABG) surgery, the use of cangrelor as a bridge is associated with higher maintenance of platelet inhibition compared with placebo, according to a study published in the Jan. 18 issue of the Journal of the American Medical Association.
No Long-Term Benefit of Caffeine for Apnea in Preemies
TUESDAY, Jan. 17 (HealthDay News) -- Neonatal caffeine therapy for apnea of prematurity is no longer associated with increased survival without disability when assessed at five-year follow-up, according to a study published in the Jan. 18 issue of the Journal of the American Medical Association.
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Prevalence of Obesity Unchanged in Adults/Children
TUESDAY, Jan. 17 (HealthDay News) -- The prevalence of obesity in adults and children/adolescents in the United States has remained unchanged in recent years, according to two studies published online Jan. 17 in the Journal of the American Medical Association.
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Comorbidities Affect Hospital Costs After Hip Fracture
TUESDAY, Jan. 17 (HealthDay News) -- For older Americans with hip fracture, the presence of comorbidities is associated with increased cost of hospitalization, according to a study published in the Jan. 4 issue of The Journal of Bone & Joint Surgery.
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Untreated Sleep Apnea Linked to Cardio Mortality in Women
TUESDAY, Jan. 17 (HealthDay News) -- Untreated obstructive sleep apnea (OSA) is associated with increased cardiovascular mortality in women, but continuous positive airway pressure (CPAP) treatment reduces the risk of mortality, according to a study published in the Jan. 17 issue of the Annals of Internal Medicine.
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Low Doses of Insulin Induce an Elastogenic Effect
TUESDAY, Jan. 17 (HealthDay News) -- Insulin induces an elastogenic effect, with therapeutic doses of insulin stimulating the formation of elastic fibers in human aortic smooth muscle cell cultures, according to an experimental study published online Jan. 11 in The American Journal of Pathology.
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Endovascular Graft Approved for Tears of Aorta
MONDAY, Jan. 16 (HealthDay News) -- The U.S. Food and Drug Administration has expanded approval of an endovascular graft to include ruptures of the aorta.
Vitamin D Supplements Do Not Reduce COPD Exacerbations
MONDAY, Jan. 16 (HealthDay News) -- For patients with chronic obstructive pulmonary disease (COPD), high-dose vitamin D supplementation does not reduce the incidence of exacerbations, according to a study published in the Jan. 17 issue of the Annals of Internal Medicine.
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Patients With Breast Cancer Lack Knowledge of the Disease
MONDAY, Jan. 16 (HealthDay News) -- Many early-stage breast cancer survivors lack knowledge about their disease and report not being involved in treatment decisions, although most receive treatment consistent with their goals, according to a study published in the January issue of the Journal of the American College of Surgeons.
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Access to Quality Primary Care Reduces Mortality Risk
MONDAY, Jan. 16 (HealthDay News) -- Greater access to high-quality primary medical care that includes features of comprehensiveness, patient-centeredness, and extended office hours is associated with a reduced risk of death, according to a study published in the January/February issue of the Annals of Family Medicine.
Practice Differs for Cardiac Screening in ADHD Treatment
MONDAY, Jan. 16 (HealthDay News) -- There is considerable variation in the attitudes, barriers, and practices of pediatricians for cardiac screening before initiation of stimulant treatment for attention-deficit/hyperactivity disorder (ADHD), according to a study published online Jan 16 in Pediatrics.
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Hyaluronic Acid Similar to Placebo for Ankle Arthritis
MONDAY, Jan. 16 (HealthDay News) -- A single intra-articular injection of hyaluronic acid was no more effective in treating osteoarthritis of the ankle than an injection of normal saline solution, according to a study published in the Jan. 4 issue of The Journal of Bone & Joint Surgery.
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Maternal Asthma Meds Not Linked to Most Birth Defects
MONDAY, Jan. 16 (HealthDay News) -- Use of asthma medications in early pregnancy is not associated with most birth defects, but positive associations are present for a few specific defects, including isolated esophageal and anorectal atresia and omphalocele, according to a study published online Jan. 16 in Pediatrics.
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Integrated Diabetes-Depression Treatment Improves Outcome
MONDAY, Jan. 16 (HealthDay News) -- Integrating the treatment of type 2 diabetes and depression improves outcomes, including glycemic control and depression, for patients in the primary care setting, according to a study published in the January/February issue of the Annals of Family Medicine.
Young Women Often Perceive Their Weight Gain Inaccurately
FRIDAY, Jan. 13 (HealthDay News) -- For young women of reproductive age, self-perceptions of weight gain are often inaccurate, and are affected by race/ethnicity and contraceptive use, according to a study published online Dec. 2 in the Journal of Women's Health.
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Surgery Beats Non-Op Care for Intervertebral Disc Herniation
FRIDAY, Jan. 13 (HealthDay News) -- Surgery is more effective than nonoperative treatment for patients with intervertebral disc herniation (IDH), with marital status, joint problems, and symptom trend at baseline identified as significant modifiers of treatment effect, according to a study published in the Jan. 15 issue of Spine.
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Fatal Case of Measles Without Rash Found in Young Woman
FRIDAY, Jan. 13 (HealthDay News) -- A fatality from measles with acute respiratory distress syndrome (ARDS), but without rash, has been reported, according to a study published online Jan. 11 in the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.
Lower Rate of IBD for Women Living in Sunnier Climates
FRIDAY, Jan. 13 (HealthDay News) -- Living in the southern latitudes is associated with a reduced risk of developing inflammatory bowel disease (IBD), with residence at age 30 most strongly related to the risk, according to a study published online Jan. 11 in Gut.
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U.S. Health Care Expenditure Still Unevenly Distributed
FRIDAY, Jan. 13 (HealthDay News) -- Health care expenditure in the United States is still unevenly distributed, with 1 percent of the population accounting for approximately 20 percent of expenditure in 2008 and 2009, according to a January statistical brief published by the Agency for Healthcare Research and Quality (AHRQ).
Thromboprophylaxis Rate Low for Knee Arthroplasty in Taiwan
FRIDAY, Jan. 13 (HealthDay News) -- Pharmacologic thromboprophylaxis for Taiwanese patients undergoing total knee arthroplasty (TKA) is very low, at 2.2 percent, which may correlate with the low incidence of post-surgery venous thromboembolism (VTE), according to a study published in the January issue of the Journal of Thrombosis and Haemostasis.
Increased CD4+ T Cells in Peripheral Blood of Obese
FRIDAY, Jan. 13 (HealthDay News) -- Morbidly obese individuals have a selective increase in CD4+ T cells in the peripheral blood T-cell compartment, according to a study published online Jan. 6 in Diabetes.
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Inflammatory Bowel Disease Increasing in U.S., Europe
FRIDAY, Jan. 13 (HealthDay News) -- The incidence and prevalence of inflammatory bowel disease (IBD) are highest in Europe and North America, and are increasing, according to a review published in the January issue of Gastroenterology.
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Cirrhosis Ups Disability, Health Care Utilization in Seniors
FRIDAY, Jan. 13 (HealthDay News) -- Older individuals with cirrhosis have higher rates of health care utilization, disability, and requirements for informal caregiving than those without cirrhosis, according to a study published in the January issue of Hepatology.
Maternal Antidepressants Up Infant Pulmonary Hypertension
FRIDAY, Jan. 13 (HealthDay News) -- Use of antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs), during pregnancy increases the risk of persistent pulmonary hypertension in newborns, according to a study published online Jan. 12 in BMJ.
Foot Tapping Assesses Motor Function in Cervical Myelopathy
THURSDAY, Jan. 12 (HealthDay News) -- The foot tapping test (FTT) can be used to quantitatively assess lower extremity motor function in patients with cervical myelopathy, according to a study published in the Jan. 15 issue of Spine.
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Gene Variant Identified in Families With Cold Urticaria
THURSDAY, Jan. 12 (HealthDay News) -- The PLCG2 gene, which encodes phospholipase Cγ2, has been found to be associated with a dominantly inherited medical condition causing cold urticaria, immunodeficiency, and autoimmunity, according to a study published online Jan. 11 in the New England Journal of Medicine.
Low Risk of Cardiac Arrest in Marathon Runners
THURSDAY, Jan. 12 (HealthDay News) -- While the overall risk of cardiac arrest during a marathon or half-marathon is low, the risk is higher for those participating in marathons than half-marathons and for men than women, particularly for men with underlying hypertrophic cardiomyopathy or atherosclerotic coronary disease, according to a study published in the Jan. 12 issue of the New England Journal of Medicine.
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Stem Cell Therapy Shows Promise for Type 1 Diabetes
THURSDAY, Jan. 12 (HealthDay News) -- "Re-educating" lymphocytes from patients with type 1 diabetes through exposure to cord blood-derived multipotent stem cells (CB-SCs) is safe and may reverse autoimmunity, according to a study published online Jan. 10 in BMC Medicine.
Novel Anticancer Agents ID'd From NIH Drug Collection
THURSDAY, Jan. 12 (HealthDay News) -- Quantitative high-throughput screening (qHTS) of a large pharmaceutical collection can identify novel agents with anticancer activity, according to a study published online Dec. 14 in the Journal of Clinical Endocrinology & Metabolism.
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Physical Activity in Work or Leisure Tied to Lower MI Risk
THURSDAY, Jan. 12 (HealthDay News) -- Physical activity during work or leisure time is associated with a significantly lower risk of myocardial infarction (MI), according to a multinational study published online Jan. 11 in the European Heart Journal.
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Parabens Seen in Almost All Breast Mastectomy Samples
THURSDAY, Jan. 12 (HealthDay News) -- One or more esters of p-hydroxybenzoic acid (parabens) are seen in 99 percent of post-mastectomy, primary breast cancer tissue samples, and their concentrations vary within and between breasts, according to a study published online Jan. 12 in the Journal of Applied Toxicology.
Subclinical Tachyarrhythmias Tied to Increased Risk of Stroke
WEDNESDAY, Jan. 11 (HealthDay News) -- Subclinical atrial tachyarrhythmias, which occur in approximately 10 percent of patients in the first three months after pacemaker or defibrillator implantation, are associated with an increased risk of clinical atrial fibrillation, stroke, and systemic embolism, according to a study published in the Jan. 12 issue of the New England Journal of Medicine.
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CDC: 2010 Saw Decrease in Age-Adjusted Death Rates
WEDNESDAY, Jan. 11 (HealthDay News) -- From 2009 to 2010, age-adjusted death rates decreased and life expectancy increased, according to a Jan. 11 report published by the U.S. Centers for Disease Control and Prevention.
Gene Variant Linked to Hereditary Prostate Cancer
WEDNESDAY, Jan. 11 (HealthDay News) -- A mutation in a gene important in prostate development is associated with a higher risk of hereditary prostate cancer, particularly early-onset cancers, according to a study published in the Jan. 12 issue of the New England Journal of Medicine.
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Medicare Fitness-Membership Benefits Attract Healthy People
WEDNESDAY, Jan. 11 (HealthDay News) -- Medicare Advantage plans that offer fitness-membership benefits attract a healthier population than control plans that offer no such benefits, according to a study published in the Jan. 12 issue of the New England Journal of Medicine.
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Rx Provides Fast Relief of Pain, Urgency of Interstitial Cystitis
WEDNESDAY, Jan. 11 (HealthDay News) -- Alkalinized lidocaine plus heparin provides significant and immediate relief from the pain and urgency symptoms of interstitial cystitis (IC) for 12 hours after treatment, according to a study published in the January issue of the Journal of Sexual Medicine.
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Complications Increase With Delay of BP Control in Diabetes
WEDNESDAY, Jan. 11 (HealthDay News) -- For middle-aged patients with newly-diagnosed type 2 diabetes, the impact of a delay in controlling systolic blood pressure depends on the length of the delay, according to a study published online Jan. 4 in the Journal of General Internal Medicine.
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Insufficient Evidence to Recommend Prognostic Indices
WEDNESDAY, Jan. 11 (HealthDay News) -- There is insufficient evidence to recommend the widespread clinical use of validated prognostic indices to predict the risk of mortality in older adults, according to a review published in the Jan. 11 issue of the Journal of the American Medical Association.
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Asian-American Heart Attack Care Now Similar to Whites
WEDNESDAY, Jan. 11 (HealthDay News) -- Recently, the quality of care following acute myocardial infarction (AMI) has improved for Asian-American and white patients, and the differences in care between Asian and white patients have also been reduced, according to a study published online Jan. 10 in Circulation: Cardiovascular Quality and Outcomes.
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GLP-1R Agonists Found Effective for Weight Loss
WEDNESDAY, Jan. 11 (HealthDay News) -- Treatment with glucagon-like peptide-1 receptor (GLP-1R) agonists for at least 20 weeks leads to weight loss in obese or overweight patients with or without type 2 diabetes mellitus, according to a study published online Jan. 11 in BMJ.
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Dementia Associated With More Hospital Admissions
TUESDAY, Jan. 10 (HealthDay News) -- Hospital admission rates for all causes, and for ambulatory care-sensitive conditions (ACSCs), are significantly higher among patients with dementia compared to older patients without dementia, according to a study published in the Jan. 11 issue of the Journal of the American Medical Association.
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CDC: Binge Drinking Prevalence High in United States
TUESDAY, Jan. 10 (HealthDay News) -- About one in six adults in the United States regularly engages in binge drinking, which accounts for more than 40,000 alcohol-related deaths every year, according to research published in the Jan. 10 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.
Too High, Too Low Serum Potassium Linked to Mortality
TUESDAY, Jan. 10 (HealthDay News) -- Patients hospitalized after an acute myocardial infarction (AMI) with post-admission serum potassium levels between 3.5 and 4.5 mEq/L (milliEquivalents per liter) have a lower risk of death than those with higher or lower levels, according to a study published in the Jan. 11 issue of the Journal of the American Medical Association.
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Memantine Has No Impact on Cognition in Down's Syndrome
TUESDAY, Jan. 10 (HealthDay News) -- Memantine does not prevent a decline in cognition or function in adults with Down's syndrome, according to a study published online Jan. 10 in The Lancet.
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Nicotine Replacement Therapy Doesn't Avert Smoking Relapse
TUESDAY, Jan. 10 (HealthDay News) -- For individuals who have quit smoking, use of nicotine replacement therapy (NRT) may not impact relapse rates, according to a meta-analysis published online Jan. 10 in Tobacco Control.
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Diabetes Lifestyle Intervention Program Could Save Billions
TUESDAY, Jan. 10 (HealthDay News) -- Modeling suggests that a lifestyle intervention program could prevent thousands of cases of diabetes and save billions of dollars; and wide-scale implementation of evidence-based interventions may be able to curb diabetes and its complications, according to two studies published in the January issue of Health Affairs.
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Benefit of Aspirin in Primary Prevention Questioned
TUESDAY, Jan. 10 (HealthDay News) -- For individuals without prior cardiovascular disease (CVD), aspirin prophylaxis does not reduce cardiovascular death or cancer mortality, although it is associated with reductions in nonfatal myocardial infarction (MI), according to a meta-analysis published online Jan. 9 in the Archives of Internal Medicine.
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A Broken Heart Does Increase Heart Attack Risk
TUESDAY, Jan. 10 (HealthDay News) -- The death of a significant person in someone's life is associated with a significantly increased risk of acute myocardial infarction (MI) for the grieving individual in the days following the death, according to a study published online Jan. 9 in Circulation.
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Long-Term Prognostic Value of Dobutamine Stress Echo Limited
TUESDAY, Jan. 10 (HealthDay News) -- Dobutamine stress echocardiography (DSE) has limited long-term predictive value for patients with diabetes who are unable to perform an exercise stress test, particularly during the first seven years after initial testing, according to a study published online Jan. 6 in Diabetes Care.
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Losartan Halts Smoke-Related Lung Damage in Mice
TUESDAY, Jan. 10 (HealthDay News) -- Losartan, an angiotensin receptor type 1 blocker used to antagonize transforming growth factor (TGF)-β, can prevent cigarette smoke (CS)-induced lung damage in a mouse model, according to a study published in the Jan. 3 issue of the Journal of Clinical Investigation.
Transdermal Nicotine May Benefit Cognitive Impairment
TUESDAY, Jan. 10 (HealthDay News) -- For nonsmokers with amnestic mild cognitive impairment (MCI), use of a transdermal nicotine patch for six months is associated with improved cognitive test performance, but not clinical global impression of change, according to a pilot study published in the Jan. 10 issue of Neurology.
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Acupuncture May Have Minor Effect in Migraine Prevention
MONDAY, Jan. 9 (HealthDay News) -- For patients with migraine, acupuncture may have a minor clinical prophylactic effect, compared with sham acupuncture, according to a study published online Jan. 9 in CMAJ, the journal of the Canadian Medical Association.
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Statins Increase Diabetes Risk for Postmenopausal Women
MONDAY, Jan. 9 (HealthDay News) -- Postmenopausal women taking statin medications have an increased risk of incident diabetes mellitus (DM), according to an analysis published online Jan. 9 in the Archives of Internal Medicine.
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Most Parents Communicate BRCA Test Results to Offspring
MONDAY, Jan. 9 (HealthDay News) -- The majority of parents who get tested for BRCA1/2 mutations share the test results with their offspring, according to a study published online Jan. 9 in Cancer.
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Adiponectin Tied to Dementia, Alzheimer's Risk in Women
MONDAY, Jan. 9 (HealthDay News) -- Plasma levels of adiponectin are an independent risk factor for all-cause dementia and Alzheimer's disease (AD) in women, according to a study published online Jan. 2 in the Archives of Neurology.
Back Pain Intensity Not Linked to Extent of Muscle Damage
MONDAY, Jan. 9 (HealthDay News) -- The intensity of exercise-induced low back pain is not statistically associated with the magnitude of spinal muscle damage in the lumbar erector spinae, according to a study published in the December issue of The Spine Journal.
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Post-Op QOL Poor in Some Esophageal Cancer Survivors
MONDAY, Jan. 9 (HealthDay News) -- While most esophageal cancer patients recover their pre-surgery health-related quality of life (HRQL), a notable percentage continue to suffer adverse effects from the surgery five years later, according to a study published online Jan. 3 in the Journal of Clinical Oncology.
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Larger Trabecular Holes Explain Bone Fragility in Diabetes
MONDAY, Jan. 9 (HealthDay News) -- The higher fracture risk observed in women with type 2 diabetes mellitus (T2DM) may be due, in part, to the larger average hole size and, consequently, the more porous nature of their trabecular bone microarchitecture, according to a study published in the January issue of Arthritis Care & Research.
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Rilonacept Reduces Gout Flares During Acute Urate Lowering Rx
MONDAY, Jan. 9 (HealthDay News) -- The use of rilonacept significantly reduces gout flare-ups in the first few months following initiation of urate-lowering therapy (ULT), according to research published online Jan. 4 in Arthritis & Rheumatism.
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Biomarker Patterns Indicative of Weight Loss Benefits
MONDAY, Jan. 9 (HealthDay News) -- Biomarker patterns reflect both the short-term benefits of weight reduction and the long-term cumulative benefits of healthful eating, despite partial weight regain, according to a study published online Dec. 21 in Diabetes Care.
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Antiestrogens May Counter Increased Skin Cancer Risk
MONDAY, Jan. 9 (HealthDay News) -- For breast cancer patients receiving antiestrogen therapy, there doesn't appear to be an excess risk of secondary cutaneous melanoma, according to a study published in the January issue of Cancer Prevention Research.
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No Mortality Benefit for Annual Prostate Cancer Screening
FRIDAY, Jan. 6 (HealthDay News) -- There is no evidence of a mortality benefit for organized annual prostate cancer screening versus usual care, according to a study published online Jan. 6 in the Journal of the National Cancer Institute.
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New Criteria ID Fewer Cases of Post-Op Diabetes Remission
FRIDAY, Jan. 6 (HealthDay News) -- Fewer patients with type 2 diabetes achieve diabetes remission following weight loss surgery, when employing the new, stricter criteria for diabetes remission issued by the American Diabetes Association (ADA), according to a study published in the January issue of the British Journal of Surgery.
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Glucose-Lowering Algorithm Safe in Coronary Care Unit
FRIDAY, Jan. 6 (HealthDay News) -- In coronary care unit (CCU) patients, a paper-based glucose-lowering algorithm with target serum glucose levels of 5.0 to 6.5 mmol/L (90 to 117 mg/dL) can be safely implemented, but further studies are needed to assess cardiovascular outcomes, according to research published in the January issue of Diabetes Care.
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Three Novel Multiple Sclerosis Susceptibility Loci Identified
FRIDAY, Jan. 6 (HealthDay News) -- Three novel multiple sclerosis (MS) genetic susceptibility loci have been identified, according to a meta-analysis published in the December issue of the Annals of Neurology.
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Hypoglycemia in Intensive Diabetes Control May Up Survival
FRIDAY, Jan. 6 (HealthDay News) -- For adults with type 2 diabetes, recognized and unrecognized hypoglycemia is more common in those with intensive blood sugar control, and is associated with a small but significant reduction in the risk of mortality, according to a study published online Dec. 16 in Diabetes Care.
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Cognitive Decline May Begin As Early As Age 45
FRIDAY, Jan. 6 (HealthDay News) -- Cognitive functioning, including memory, reasoning, and comprehension skills, can start to deteriorate as early as age 45 and declines even faster in men and women over age 65, according to a large, prospective study published online Jan. 5 in BMJ.
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Hand Bone Loss Predicts Radiographic Progression in RA
FRIDAY, Jan. 6 (HealthDay News) -- Hand bone loss during the first year of treatment of rheumatoid arthritis (RA) is associated with a high likelihood of radiographic progression, but it is not associated with long-term patient-reported outcomes, according to a study published in the January issue of Arthritis Care & Research.
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Exercise Benefits Insulin-Treated Obese Patients With Diabetes
FRIDAY, Jan. 6 (HealthDay News) -- Supervised mixed (aerobic and resistance) exercise is effective in improving hemoglobin A1c (HbA1c) and cardiovascular disease (CVD) risk related to insulin treatment in overweight and obese patients with type 2 diabetes, according to a study published in the January issue of Diabetes Care.
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Few With Diabetes Risk See Need for Lifestyle Counseling
FRIDAY, Jan. 6 (HealthDay News) -- Many patients who are at risk for developing type 2 diabetes do not perceive the need for lifestyle counseling, and even among those who see the need for counseling, less than half actually attend lifestyle interventions, according to a study published online Dec. 21 in Diabetes Care.
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HCV Antivirals Cost-Effective for Injecting Drug Users
FRIDAY, Jan. 6 (HealthDay News) -- Antivirals are cost-effective for injecting drug users (IDUs) where the chronic prevalence of hepatitis C virus (HCV) infection is less than 60 percent, according to a study published in the January issue of Hepatology.
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Deep Brain Stimulation Found Effective for Severe Depression
FRIDAY, Jan. 6 (HealthDay News) -- Deep brain stimulation has been shown to be a safe and effective intervention for treatment-resistant depression (TRD) in patients with major depressive disorder (MDD) or bipolar II (BP) disorder, according to a study published online Jan. 2 in the Archives of General Psychiatry.
Shedding Persists in Herpes Even With High-Dose Antivirals
THURSDAY, Jan. 5 (HealthDay News) -- Short episodes of subclinical shedding or reactivation persist in herpes simplex virus type 2 (HSV-2) infection, even in patients on high doses of antiviral therapy, according to a study published online Jan. 5 in The Lancet.
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In-Hospital, 30-Day Standardized Mortality Measures Differ
THURSDAY, Jan. 5 (HealthDay News) -- The mean risk-standardized mortality rates (RSMRs) differ for in-hospital and 30-day models, with wide variability across U.S. hospitals, according to a study published in the Jan. 3 issue of the Annals of Internal Medicine.
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Potential Genetic Marker of Colorectal Cancer Risk Found
THURSDAY, Jan. 5 (HealthDay News) -- There is an association between an increase in the degree of germline allele-specific expression (ASE) of the adenomatous polyposis coli (APC) gene and the risk of common forms of colorectal cancer (CRC), according to a study published in the January issue of Gastroenterology.
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Hyperuricemia Is Independent Risk Factor for Incident CKD
THURSDAY, Jan. 5 (HealthDay News) -- Patients with type 2 diabetes and normal kidney function are twice as likely to develop incident chronic kidney disease (CKD) if they have hyperuricemia, according to a study published in the January issue of Diabetes Care.
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Cancer Incidence, Mortality Higher in Adults With Diabetes
THURSDAY, Jan. 5 (HealthDay News) -- The incidence of cancer and the mortality rate due to cancer is higher in people with type 2 diabetes compared to those without the condition, according to a study published in the January issue of Diabetes Care.
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Formula Diet Aids Weight Loss, Nutritional Gains in Obese
THURSDAY, Jan. 5 (HealthDay News) -- A 16-week formula-based diet program significantly improves the nutritional status and bone health in obese patients with osteoarthritis, according to a study published online Dec. 21 in the European Journal of Clinical Nutrition.
Spinal Manipulation Superior to Medication for Neck Pain
THURSDAY, Jan. 5 (HealthDay News) -- For patients with acute and subacute nonspecific neck pain, symptoms improved with spinal manipulation therapy (SMT), medication, and home exercise, but spinal manipulation was found to be the most effective method for both short-term and long-term pain relief, according to a study published online Jan. 2 in the Annals of Internal Medicine.
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Vibratory Sense Unimpaired in Knee-Injured Patients
THURSDAY, Jan. 5 (HealthDay News) -- For knee-injured patients, the vibratory perception threshold (VPT) is not impaired in those at high risk of knee osteoarthritis, according to a study published in the January issue of Arthritis Care & Research.
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Epilepsy, HIV Drug Combination Therapies Require Caution
THURSDAY, Jan. 5 (HealthDay News) -- Antiepileptic drugs (AEDs) should be used with caution in individuals with HIV/AIDS, due to potential interactions between AEDs and antiretroviral agents (ARVs), according to new guidelines issued by the American Academy of Neurology, published online Jan. 4 in Neurology.
HPV Vaccine Doesn't Lull Girls Into Complacency About Sex
THURSDAY, Jan. 5 (HealthDay News) -- Few teenage girls receiving the human papillomavirus (HPV) vaccine perceive a reduced need for safer sexual behavior following their first inoculation, according to a study published in the January issue of the Archives of Pediatrics & Adolescent Medicine.
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Novel Hepatitis C Vaccine Induces T Cell Responses
THURSDAY, Jan. 5 (HealthDay News) -- Adenovirus-based vaccines can generate strong, broad, long-lasting, and functional T cell responses against hepatitis C virus (HCV) in healthy people, according to a study published in the Jan. 4 issue of Science Translational Medicine.
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New Predictors of Treatment Response Identified for CRC
WEDNESDAY, Jan. 4 (HealthDay News) -- In colorectal cancer patients, hypermethylation of the gene encoding transcription factor AP-2 epsilon (TFAP2E), which targets a gene involved in chemoresistance (dickkopf homolog 4 protein [DKK4]), is associated with treatment resistance to fluorouracil but not irinotecan or oxaliplatin, according to a study published in the Jan. 5 issue of the New England Journal of Medicine.
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Vaccine Helps Prevent HSV-1 Genital Disease and Infection
WEDNESDAY, Jan. 4 (HealthDay News) -- An investigational vaccine effectively prevents herpes simplex virus type 1 (HSV-1) but not HSV type 2 (HSV-2) genital disease and infection, according to a study published in the Jan. 5 issue of the New England Journal of Medicine.
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Cancer-Related Mortality Continues to Decrease
WEDNESDAY, Jan. 4 (HealthDay News) -- Overall cancer rates have decreased for men and remained stable for women, but mortality from cancer has declined for both men and women, according to a report from the American Cancer Society published online Jan. 4 in CA: A Cancer Journal for Clinicians.
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Dietary Protein Affects Energy Expenditure, Not Body Fat
TUESDAY, Jan. 3 (HealthDay News) -- For individuals in a controlled setting, the protein content of a diet affects energy expenditure and storage of lean mass, but does not impact body fat storage, according to a study published in the Jan. 4 issue of the Journal of the American Medical Association.
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Gene Involved in Familial Pancreatic Cancer Identified
WEDNESDAY, Jan. 4 (HealthDay News) -- Specific ataxia telangiectasia mutated (ATM) gene mutations that increase the hereditary risk of familial pancreatic ductal adenocarcinoma have been identified, according to a study published online Dec. 29 in Cancer Discovery.
Most Type 2 Diabetes, CAD Patients Present With Angina
WEDNESDAY, Jan. 4 (HealthDay News) -- A large proportion of patients with type 2 diabetes mellitus and documented stable coronary artery disease have symptoms of angina, and the nature of symptom presentation may be associated with the type of previous revascularization, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.
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Vasoepididymostomy Ups Patency in Obstructive Azoospermia
WEDNESDAY, Jan. 4 (HealthDay News) -- For men with idiopathic obstructive azoospermia, longitudinal intussusception vasoepididymostomy (LIVE; microsurgical vasoepididymostomy) achieves good patency rates, according to a study published in the January issue of Urology.
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Burden of Treatment in Diabetes Rarely Addressed
WEDNESDAY, Jan. 4 (HealthDay News) -- Although the burden of diabetes treatments is discussed in more than 90 percent of primary care office visits, problem-solving efforts are made in only about one-third of cases, according to a study published in the January issue of Diabetes Care.
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Donor Bisphosphonate Use OK With Demineralized Bone Matrix
WEDNESDAY, Jan. 4 (HealthDay News) -- Demineralized bone matrix (DBM) derived from donors who used bisphosphonates is safe and effective in its ability to induce bone formation, according to a study published in the Dec. 21 issue of The Journal of Bone & Joint Surgery.
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Neurostimulation Improves Swallowing After Stroke
WEDNESDAY, Jan. 4 (HealthDay News) -- A new neurostimulation technique called paired associated stimulation (PAS), which combines peripheral stimulation of the targeted muscle with cortical stimulation of the targeted muscle's representational area, may be useful in the rehabilitation of patients with dysphagia due to stroke, according to a study published in the January issue of Gastroenterology.
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Usual Care Doesn't Stop Muscle Loss in Idiopathic Fracture
WEDNESDAY, Jan. 4 (HealthDay News) -- Routine management of men with idiopathic vertebral fracture has no effect on observed muscle loss; and patients still have significantly lower physical functioning and quality of life than controls after six years of follow-up, according to a study published in the January issue of Arthritis Care & Research.
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Pneumonia Vaccine Approved for Older People
TUESDAY, Jan. 3 (HealthDay News) -- The Prevnar 13 bacterial pneumonia vaccine has been approved for people aged 50 and older, the U.S. Food and Drug Administration said.
Bariatric Surgery Tied to Reduced CVD Events, Mortality
TUESDAY, Jan. 3 (HealthDay News) -- For obese individuals, bariatric surgery is associated with significantly reduced incidence of cardiovascular events, and decreased cardiovascular death, versus usual care, according to a study published in the Jan. 4 issue of the Journal of the American Medical Association.
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Multiple Blockages, U.S. Heart Attack Care Ups Readmissions
TUESDAY, Jan. 3 (HealthDay News) -- Patients treated for heart attacks in the United States have shorter initial hospital stays but significantly higher rates of 30-day readmission compared with patients in other countries, according to a study published in the Jan. 4 issue of the Journal of the American Medical Association.
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Epidural Steroids Temporarily Up Blood Glucose in Diabetes
TUESDAY, Jan. 3 (HealthDay News) -- Epidural steroid injections (ESIs) significantly increase the blood glucose levels in patients with diabetes mellitus, but the effect lasts less than two days, according to a study published in the Jan. 1 issue of Spine.
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Traditional, Disease Risk Factors ID'd in SLE Osteoporosis
TUESDAY, Jan. 3 (HealthDay News) -- For patients with systemic lupus erythematosus (SLE), the etiology of osteoporosis is multifactorial, encompassing traditional risk factors and SLE-related factors; and there is an increased fracture risk, according to a review published in the January issue of Arthritis Care & Research.
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Psych Symptoms Affect Key Subset With Celiac Disease
TUESDAY, Jan. 3 (HealthDay News) -- A substantial subset of women with celiac disease report clinically relevant symptoms of depression and disordered eating, despite high adherence to a gluten-free diet, according to a study published online in Chronic Illness.
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CDC: Lean Response Ups Lab Surge Capacity During Pandemic
TUESDAY, Jan. 3 (HealthDay News) -- Implementation of Lean methods can improve the surge capacity of a laboratory, according to a study published in the January issue of the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.
Infarcts, Hippocampal Volume Independently Linked to Memory
TUESDAY, Jan. 3 (HealthDay News) -- In elderly individuals without dementia, the presence of brain infarcts and a smaller hippocampal volume are independently associated with poor memory, according to a study published in the Jan 3. issue of Neurology.
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Hormone Receptor Levels Predict Trastuzumab Effect
TUESDAY, Jan. 3 (HealthDay News) -- Patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer whose tumors also express hormone receptors may be less responsive to the addition of trastuzumab to chemotherapy, suggesting that hormone receptor expression has a predictive role in determining response to therapy, according to research published in the Jan. 1 issue of Cancer.
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Lack of Resources Barrier to Vets' Weight-Management Plan
TUESDAY, Jan. 3 (HealthDay News) -- Successful implementation of the MOVE! weight-management program in Veterans Health Administration medical facilities depends upon organizational readiness and an innovation champion, according to a study published in the January issue of the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.
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